Lipid-Protein Interactions in Cellular Processes

Group leader
Alicia Alonso
Phone
+34 946 01 3354
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

In our group we research lipid-protein interactions in different processes where membrane remodelling is taking place. In particular, we are now concentrating our studies on the autophagosome generation/elongation and further fusion with the lysosomes. Our methodological approach is multidisciplinary with a combination of biophysical, cellular biology and nanotechnological techniques.

Group members
Ikerbasque Research Fellow
University Professor
CSIC Scientist
Research Technician
Research Technician
Publications

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Ballesteros U, Iriondo MN, Varela YR, Goñi FM, Alonso A, Montes LR, Etxaniz A

The N-terminal region of the ATG8 autophagy protein LC3C is essential for its membrane fusion properties
Int J Biol Macromol. 2024 Mar;262(Pt 1):129835
doi: 10.1016/j.ijbiomac.2024.129835

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Varela YR, Iriondo MN, Goñi FM, Alonso A, Montes LR

Ceramide regulation of autophagy: A biophysical approach
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159444
doi: 10.1016/j.bbalip.2023.159444

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Iriondo MN, Alonso A.

Vesicle tethering and fusion promoted by LC3/GABARAP proteins is modulated by the ATG12-ATG5-ATG16L1 complex
Autophagy. 2023 Oct;19(10):2827-2829
DOI: 10.1080/15548627.2023.2202557

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Varela YR, González-Ramírez EJ, Iriondo MN, Ballesteros U, Etxaniz A, Montes LR, Goñi FM, Alonso A.

Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide
Int J Mol Sci. 2023 Mar 7;24(6):5080
DOI: 10.3390/ijms24065080

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Iriondo MN, Etxaniz A, Varela YR, Ballesteros U, Lázaro M, Valle M, Fracchiolla D, Martens S, Montes LR, Goñi FM, Alonso A.

Effect of ATG12-ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
Cell Mol Life Sci. 2023 Feb 2;80(2):56
DOI: 10.1007/s00018-023-04704-z

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Varela YR, Alonso A.

LC3/GABARAP binding to fluid membranes is potentiated by ceramide
Autophagy. 2023 Apr;19(4):1371-1373
DOI: 10.1080/15548627.2022.2136821

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Varela YR, Iriondo MN, Etxaniz A, Ballesteros U, Montes LR, Goñi FM, Alonso A.

Ceramide enhances binding of LC3/GABARAP autophagy proteins to cardiolipin-containing membranes
Int J Biol Macromol. 2022 Sep 30;217:748-760
DOI: 10.1016/j.ijbiomac.2022.07.032