Lipid-Protein Interactions in Cellular Processes

Group leader
Alicia Alonso
+34 946 01 3354

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

In our group we research lipid-protein interactions in different processes where membrane remodelling is taking place. In particular, we are now concentrating our studies on the autophagosome generation/elongation and further fusion with the lysosomes. Our methodological approach is multidisciplinary with a combination of biophysical, cellular biology and nanotechnological techniques.

Group members
Ikerbasque Research Fellow
University Professor
CSIC Scientist
Research Technician
Research Technician

Read the article

Ballesteros U, Iriondo MN, Varela YR, Goñi FM, Alonso A, Montes LR, Etxaniz A

The N-terminal region of the ATG8 autophagy protein LC3C is essential for its membrane fusion properties
Int J Biol Macromol. 2024 Mar;262(Pt 1):129835
doi: 10.1016/j.ijbiomac.2024.129835

Read the article

Varela YR, Iriondo MN, Goñi FM, Alonso A, Montes LR

Ceramide regulation of autophagy: A biophysical approach
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159444
doi: 10.1016/j.bbalip.2023.159444

Read the article

Iriondo MN, Alonso A.

Vesicle tethering and fusion promoted by LC3/GABARAP proteins is modulated by the ATG12-ATG5-ATG16L1 complex
Autophagy. 2023 Oct;19(10):2827-2829
DOI: 10.1080/15548627.2023.2202557

Read the article

Varela YR, González-Ramírez EJ, Iriondo MN, Ballesteros U, Etxaniz A, Montes LR, Goñi FM, Alonso A.

Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide
Int J Mol Sci. 2023 Mar 7;24(6):5080
DOI: 10.3390/ijms24065080

Read the article

Iriondo MN, Etxaniz A, Varela YR, Ballesteros U, Lázaro M, Valle M, Fracchiolla D, Martens S, Montes LR, Goñi FM, Alonso A.

Effect of ATG12-ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
Cell Mol Life Sci. 2023 Feb 2;80(2):56
DOI: 10.1007/s00018-023-04704-z

Read the article

Varela YR, Alonso A.

LC3/GABARAP binding to fluid membranes is potentiated by ceramide
Autophagy. 2023 Apr;19(4):1371-1373
DOI: 10.1080/15548627.2022.2136821

Read the article

Varela YR, Iriondo MN, Etxaniz A, Ballesteros U, Montes LR, Goñi FM, Alonso A.

Ceramide enhances binding of LC3/GABARAP autophagy proteins to cardiolipin-containing membranes
Int J Biol Macromol. 2022 Sep 30;217:748-760
DOI: 10.1016/j.ijbiomac.2022.07.032