FluoroNanoTools Laboratory

Group leader
Mónica Carril
Phone
+34 946 018 165
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

The group is mainly focused on the use of fluorinated nanostructures as enabling tools to learn about dynamic biological processes. On the one hand, we use fluorine as a label that can be tuned for the design of OFF/ON, or Smart, contrast agents based on 19F MRI or as a reporter for the study of protein corona in complex environments via fluorine based magnetic resonance (19F NMR, MRS, or MRI). On the other hand, we take advantage of the particular properties of organic fluorine for encapsulation and delivery purposes inside cells. In this field, we aim at tuning the nanoparticles’ surface to achieve controlled interaction with cell membranes to direct and improve delivery.

Group members
Ikerbasque Research Associate
Publications

Arango JM, Padro D, Blanco J, Lopez-Fernandez S, Castellnou P, Villa-Valverde P, Ruiz-Cabello J, Martin A, Carril M.

Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging. ACS Applied Materials & Interfaces. 2021 Mar 13(11), 12941-12949.
doi: 10.1021/acsami.1c01291

Atabakhshi-Kashi M, Carril M, Mahdavi H, ParakWJ, Carrillo-Carrion C, Khajeh K.

In Vitro Cellular Uptake Studies of Self-Assembled Fluorinated Nanoparticles Labelled with Antibodies. Nanomaterials. 2021 Aug 11(8), 1906. PMID: 34443736.
doi: 10.3390/nano11081906

Feiner IVJ, Pulagam KR, Gómez‐Vallejo V, Zamacola K, Baz Z, Caffarel MM, Lawrie CH, Ruiz-de-Angulo A, Carril M, Llop J.

Therapeutic pretargeting with gold nanoparticles as drug candidates for boron neutron capture therapy. Particle & Particle Systems Characterization. 2020 Dec 37(12), 2000200.
doi: 10.1002/ppsc.202000200

Padro D, Cienskowski P, Lopez‐Fernandez S, Chakraborty I, Carrillo‐Carrion C, Feliu N, Parak WJ, Carril M.

Toward Diffusion Measurements of Colloidal Nanoparticles in Biological Environments by Nuclear Magnetic Resonance. Small. 2020 Sept 16(36), 2001160. PMID: 32431081.
doi: 10.1002/smll.202001160

Sanchez-Cano C, Carril M.

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces. Int J Mol Sci. 2020 Feb 3;21(3). pii:E1007. PMID: 32028729.
doi: 10.3390/ijms21031007

Argudo PG, Carril M, Martín-Romero MT, Giner-Casares JJ, Carrillo-Carrión C.

Surface-Active Fluorinated Quantum Dots for Enhanced Cellular Uptake. Chemistry: A European Journal. 2019 Jan 2;25(1):195-199. PMID: 30257052.
doi: 10.1002/chem.201804704

Argudo PG, Martín-Romero MT, Camacho L, Carril M, Carrillo-Carrión C, Giner-Casares JJ.

Fluorinated CdSe/ZnS quantum dots: Interactions with cell membrane. Colloids Surf B Biointerfaces. 2019 Jan 1;173:148-154. PMID: 30286431.
doi: 10.1002/chem.201804704

Gabrielli L, Carril M, Padro D, Mancin F.

Multimodal F-19 NMR Dopamine Detection and Imaging with a Nanoparticle-Based Displacement Assay. Chemistry: A European Journal. 2018 Sep 3;24(49):13036-13042. PMID: 29883527.
doi: 10.1002/chem.201802482

Carrillo-Carrión C, Gallego M, Parak WJ, Carril M.

Study of Fluorinated Quantum Dots-Protein Interactions at the Oil/Water Interface by Interfacial Surface Tension Changes. Materials (Basel). 2018 May 8;11(5). pii: E750. PMID: 29738437.
doi: 10.3390/ma11050750

Carrillo-Carrion C, Atabakhshi-Kashi M, Carril M, Khajeh K, Parak WJ.

Taking Advantage of Hydrophobic Fluorine Interactions for Self-Assembled Quantum Dots as a Delivery Platform for Enzymes. Angew Chem Int Ed Engl. 2018 Apr 23;57(18):5033-5036. PMID: 29490117.
doi: 10.1002/anie.201801155