Cell and tissue mechanobiology

Our group is interested in understanding how mechanical forces regulate cellular decision-making machineries in processes such as malignancy, invasion or development. We aim to unravel mechano-molecular mechanisms in different contexts. Specifically, we work on (i) nuclear mechanotransduction, focused -but not limited- on understanding the mechanosensitivity of nucleocytoplasmic transport, (ii) mechanosensing at cell-extracellular matrix adhesions and (iii) structure and mechanics of the extracellular matrix. We embrace multidisciplinarity, working with molecular and cellular biology, from single cells to 3D organoids or tissue slices, in combination with high resolution microscopes and biophysical techniques.