Cell and tissue mechanobiology

Group leader
Ion Andreu

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

Our group is interested in understanding how mechanical forces regulate cellular decision-making machineries in processes such as malignancy, invasion or development. We aim to unravel mechano-molecular mechanisms in different contexts. Specifically, we work on (i) nuclear mechanotransduction, focused -but not limited- on understanding the mechanosensitivity of nucleocytoplasmic transport, (ii) mechanosensing at cell-extracellular matrix adhesions and (iii) structure and mechanics of the extracellular matrix. We embrace multidisciplinarity, working with molecular and cellular biology, from single cells to 3D organoids or tissue slices, in combination with high resolution microscopes and biophysical techniques.

Group members
Research Technician
Ikerbasque Research Fellow
Research Technician

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Kechagia Z, Sáez P, Gómez-González M, Canales B, Viswanadha S, Zamarbide M, Andreu I, Koorman T, Beedle AEM, Elosegui-Artola A, Derksen PWB, Trepat X, Arroyo M, Roca-Cusachs P.

The laminin-keratin link shields the nucleus from mechanical deformation and signalling
Nat Mater. 2023 Sep 14
doi: 10.1038/s41563-023-01657-3

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Abenza JF, Rossetti L, Mouelhi M, Burgués J, Andreu I, Kennedy K, Roca-Cusachs P, Marco S, García-Ojalvo J, Trepat X.

Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD
J Cell Biol. 2023 Sep 4;222(9):e202209120
doi: 10.1083/jcb.202209120

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Andreu I, Granero-Moya I, Garcia-Manyes S, Roca-Cusachs P.

Understanding the role of mechanics in nucleocytoplasmic transport
APL Bioeng. 2022 Jun 29;6(2):020901
doi: 10.1063/5.0076034

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Andreu I, Granero-Moya I, Chahare NR, Clein K, Molina-Jordán M, Beedle AEM, Elosegui-Artola A, Abenza JF, Rossetti L, Trepat X, Raveh B, Roca-Cusachs P.

Mechanical force application to the nucleus regulates nucleocytoplasmic transport
Nat Cell Biol. 2022 Jun;24(6):896-905. Epub 2022 Jun 9. PMID: 35681009.
DOI: 10.1038/s41556-022-00927-7

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Andreu I, Falcones B, Hurst S, Chahare N, Quiroga X, Le Roux AL, Kechagia Z, Beedle AEM, Elosegui-Artola A, Trepat X, Farré R, Betz T, Almendros I, Roca-Cusachs P.

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
Nat Commun. 2021 Jul 9;12(1):4229. PMID: 34244477; PMCID: PMC8270983.
DOI: 10.1038/s41467-021-24383-3

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Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P.

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.
Cell. 2017 Nov 30;171(6):1397-1410.e14. Epub 2017 Oct 26. PMID: 29107331.
DOI: 10.1016/j.cell.2017.10.008