Sphingolipids and Membrane Domains Laboratory
Sphingolipids are relatively minor components of cell membranes, but the last two decades have witnessed an increased interest in these molecules, and particularly the simplest of them ceramide and sphingosine, due to (a) their proposed role in cell signalling, and (b) their unusual biophysical properties. The latter include the tendency of ceramides to form non-lamellar structures, to permeabilise bilayers, and to promote transbilayer (flip-flop) motion of lipids. These properties were discovered in our lab. More recently we have characterised the interaction of ceramide and cholesterol, and the formation of gel-phase structures containing ceramide and cholesterol that could exist in cell membranes.
Monasterio BG, Jiménez-Rojo N, García-Arribas AB, Riezman H, Goñi FM, Alonso A.
González-Ramírez EJ, García-Arribas AB, Sot J, Goñi FM, Alonso A.
Ahyayauch H, García-Arribas AB, Masserini ME, Pantano S, Goñi FM, Alonso A.
Siavashi R, Phaterpekar T, Leung SSW, Alonso A, Goñi FM, Thewalt JL.
González-Ramírez EJ, Artetxe I, García-Arribas AB, Goñi FM, Alonso A.
Manni MM, Sot J, Arretxe E, Gil-Redondo R, Falcón-Pérez JM, Balgoma D, Alonso C, Goñi FM, Alonso A.
Fanani ML, Busto JV, Sot J, Abad JL, Fabrías G, Saiz L, Vilar JMG, Goñi FM, Maggio B, Alonso A.
Arsov Z, González-Ramírez EJ, Goñi FM, Tristram-Nagle S, Nagle JF.
Alonso A, Goñi FM.