Sphingolipids and Membrane Domains

Group leader
Félix M. Goñi
Phone
+34 946 01 2542
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

Sphingolipids are relatively minor components of cell membranes, but the last two decades have witnessed an increased interest in these molecules, and particularly the simplest of them ceramide and sphingosine, due to (a) their proposed role in cell signalling, and (b) their unusual biophysical properties. The latter include the tendency of ceramides to form non-lamellar structures, to permeabilise bilayers, and to promote transbilayer (flip-flop) motion of lipids. These properties were discovered in our lab. More recently we have characterised the interaction of ceramide and cholesterol, and the formation of gel-phase structures containing ceramide and cholesterol that could exist in cell membranes.

Group members
Postdoctoral Fellow
University Professor
Research Technician
Research Technician
Publications

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Font-Mateu J, Sanllehí P, Sot J, Abad B, Mateos N, Torreno-Pina JA, Ferrari R, Wright RHG, Garcia-Parajo MF, Joglar J, Goñi FM, Beato M
A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
Cell Mol Life Sci. 2024 Feb 22;81(1):98
doi: 10.1007/s00018-024-05116-3

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Ballesteros, U.; González-Ramirez, E.J.; de la Arada, I.; Sot, J.; Etxaniz, A.; Goñi, F.M.; Alonso, A.; Montes, L.R.

Effects of a N-maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
Int. J. Mol. Sci. 2023, 24, 16570
doi: 10.3390/ijms242316570

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Gómez-Fernández JC, Goñi FM
The Myth of The Annular Lipids
Biomedicines. 2022 Oct 22;10(11):2672
doi: 10.3390/biomedicines10112672

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Goñi FM

Sphingomyelin: What is it good for?
Biochem Biophys Res Commun. 2022 Dec 10;633:23-25
doi: 10.1016/j.bbrc.2022.08.074

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González-Ramírez EJ, Etxaniz A, Alonso A, Goñi FM
Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain
Colloids Surf B Biointerfaces. 2022 Nov;219:112855
doi: 10.1016/j.colsurfb.2022.112855

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Monasterio BG, Jiménez-Rojo N, García-Arribas AB, Riezman H, Goñi FM, Alonso A.

CHO/LY-B cell growth under limiting sphingolipid supply: Correlation between lipid composition and biophysical properties of sphingolipid-restricted cell membranes.
FASEB J. 2021 Jun;35(6):e21657.
DOI: 10.1096/fj.202001879RR

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González-Ramírez EJ, García-Arribas AB, Sot J, Goñi FM, Alonso A.

C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes.
Sci Rep. 2020 Aug 24;10(1):14085.
DOI: 10.1038/s41598-020-71008-8

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Ahyayauch H, García-Arribas AB, Masserini ME, Pantano S, Goñi FM, Alonso A.

β-Amyloid (1-42) peptide adsorbs but does not insert into ganglioside-containing phospholipid membranes in the liquid-disordered state: modelling and experimental studies.
Int J Biol Macromol. 2020 Dec 1;164:2651-2658.
DOI: 10.1016/j.ijbiomac.2020.08.165

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Siavashi R, Phaterpekar T, Leung SSW, Alonso A, Goñi FM, Thewalt JL.

Lamellar Phases Composed of Phospholipid, Cholesterol, and Ceramide, as Studied by 2H NMR.
Biophys J. 2019 Jul 23;117(2):296-306.
DOI: 10.1016/j.bpj.2019.05.027

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González-Ramírez EJ, Artetxe I, García-Arribas AB, Goñi FM, Alonso A.

Homogeneous and Heterogeneous Bilayers of Ternary Lipid Compositions Containing Equimolar Ceramide and Cholesterol.
Langmuir. 2019 Apr 16;35(15):5305-5315.
DOI: 10.1021/acs.langmuir.9b00324
"Rafts": A nickname for putative transient nanodomains.
Chem Phys Lipids. 2019 Jan;218:34-39.
DOI: 10.1016/j.chemphyslip.2018.11.006

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Manni MM, Sot J, Arretxe E, Gil-Redondo R, Falcón-Pérez JM, Balgoma D, Alonso C, Goñi FM, Alonso A.

The fatty acids of sphingomyelins and ceramides in mammalian tissues and cultured cells: Biophysical and physiological implications.
Chem Phys Lipids. 2018 Dec;217:29-34.
DOI: 10.1016/j.chemphyslip.2018.09.010

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Fanani ML, Busto JV, Sot J, Abad JL, Fabrías G, Saiz L, Vilar JMG, Goñi FM, Maggio B, Alonso A.

Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in cis-Ceramide Monolayers.
Langmuir. 2018 Oct 2;34(39):11749-11758.
DOI: 10.1021/acs.langmuir.8b02198

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Arsov Z, González-Ramírez EJ, Goñi FM, Tristram-Nagle S, Nagle JF.

Phase behavior of palmitoyl and egg sphingomyelin.
Chem Phys Lipids. 2018 Jul;213:102-110.
DOI: 10.1016/j.chemphyslip.2018.03.003

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Alonso A, Goñi FM.

The Physical Properties of Ceramides in Membranes.
Annu Rev Biophys. 2018 May 20;47:633-654.
DOI: 10.1146/annurev-biophys-070317-033309. 2.