Mechanisms of Celullar Membrane Remodelling Laboratory

Group leader
Anna Shnyrova
Phone
(+34) 94 601 8006
Address

https://shnyrovalab.wixsite.com/website

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

The main focus of the lab is on the molecular mechanisms of morphogenesis of lipid and cellular membranes at nanoscales. We want to understand how cells create, maintain and rapidly change the shape and topology of their membranes. 
Main research interests:
- Conception of novel model membrane systems
- Functional reconstitution of membrane remodelling processes
- Characterisation of protein-membrane interactions
- Double membrane remodelling

Group members
Laboratory Technician
Undergraduate student
Associate Professor
Publications

Espadas, J., Bocanegra, R., Martinez-Galvez, J. M., Largo, E., Baños-Mateos, S., Arrasate, P., … Shnyrova, A.V. (under review). 

GTP and lipids control self-assembly and functional promiscuity of Dynamin2 molecular machinery. BioRxiv, 2021.03.15.435402. https://doi.org/10.1101/2021.03.15.435402
https://doi.org/10.1101/2021.03.15.435402

Espadas, J., Pendin, D., Bocanegra, R., Escalada, A., Misticoni, G., Trevisan, T., … Daga, A. (2019)

Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon. Nature Communications, 10(1), 5327.
https://doi.org/10.1038/s41467-019-13327-7

Mahajan, M., Bharambe, N., Shang, Y., Lu, B., Mandal, A., Madan Mohan, P., … Ramachandran, R. (2021)

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission. Proceedings of the National Academy of Sciences, 118(29), e2023079118.
https://doi.org/10.1073/pnas.2023079118

Pérez-Jover, I., Madan Mohan, P., Ramachandran, R., & Shnyrova, A. V. (2022)

Reply to Roy and Pucadyil: A gain of function by a GTPase-impaired Drp1. Proceedings of the National Academy of Sciences, 119(27), e2202391119.
https://doi.org/10.1073/pnas.2202391119

Martinez Galvez, J. M., Garcia-Hernando, M., Benito-Lopez, F., Basabe-Desmonts, L., & Shnyrova, A. V. (2020)

Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes. Lab on a Chip..
https://doi.org/10.1039/D0LC00451K

Velasco-Olmo, A., Ormaetxea Gisasola, J., Martinez Galvez, J. M., Vera Lillo, J., & Shnyrova, A. V. (2019)

Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers. Scientific Reports, 9(1), 7255
https://doi.org/10.1038/s41598-019-43561-4