Mechanisms of Celullar Membrane Remodelling

Group leader
Anna Shnyrova
Phone
+34 946 01 8006
Address

Biofisika Institute (CSIC, EHU)
Science Park of the EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

The main focus of the lab is on the molecular mechanisms of morphogenesis of lipid and cellular membranes at nanoscales. We want to understand how cells create, maintain and rapidly change the shape and topology of their membranes. 
Main research interests:
- Conception of novel model membrane systems
- Functional reconstitution of membrane remodelling processes
- Characterisation of protein-membrane interactions
- Double membrane remodelling

Group members
Research Technician
PhD student
Associate Professor
Publications

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Sevilla-Lorente R, Marmol-Perez A, Gonzalez-Garcia P, Rodríguez-Miranda N, Riquelme-Gallego B, Aragon-Vela J, Martinez-Gálvez JM, Molina-Garcia P, Alcantara JMA, Garcia-Consuegra J, Cogliati S, Salmeron LM, Huertas JR, Lopez LC, Ruiz JR, Amaro-Gahete FJ

Sexual dimorphism on the acute effect of exercise in the morning vs. evening: A randomized crossover study
J Sport Health Sci. 2025 Dec;14:101021. Epub 2024 Dec 22. PMID: 39716617; PMCID: PMC11930212.
10.1016/j.jshs.2024.101021.

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Spencer RKW, Santos-Pérez I, Shnyrova AV, Müller M

Fission of double-membrane tubes under tension
Biophys J. 2024 Nov 19;123(22):3977-3996
doi: 10.1016/j.bpj.2024.10.009

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Spencer RKW, Santos-Pérez I, Rodríguez-Renovales I, Martinez Galvez JM, Shnyrova AV, Müller M

Membrane fission via transmembrane contact
Nat Commun. 2024 Mar 30;15(1):2793
doi: 10.1038/s41467-024-47122-w

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Pérez-Jover I, Rochon K, Hu D, Mahajan M, Madan Mohan P, Santos-Pérez I, Ormaetxea Gisasola J, Martinez Galvez JM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R

Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif
Nat Commun. 2024 Jan 2;15(1):52.
doi: 10.1038/s41467-023-44413-6

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Pérez-Jover, I., Madan Mohan, P., Ramachandran, R., & Shnyrova, A. V.

Reply to Roy and Pucadyil: A gain of function by a GTPase-impaired Drp1.
Proceedings of the National Academy of Sciences, 2022, 119(27), e2202391119.
DOI: 10.1073/pnas.2202391119

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Mahajan, M., Bharambe, N., Shang, Y., Lu, B., Mandal, A., Madan Mohan, P., Ramachandran, R.

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission.
Proceedings of the National Academy of Sciences, 2021, 118(29), e2023079118.
DOI: 10.1073/pnas.2023079118

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Ivchenkov DV, Kuzmin PI, Galimzyanov TR, Shnyrova AV, Bashkirov PV, Frolov VA

Nonlinear material and ionic transport through membrane nanotubes
Biochim Biophys Acta Biomembr. 2021 Oct 1;1863(10):183677
doi: 10.1016/j.bbamem.2021.183677

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Martinez Galvez, J. M., Garcia-Hernando, M., Benito-Lopez, F., Basabe-Desmonts, L., & Shnyrova, A. V.

Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes. Lab on a Chip..
Lab Chip. 2020 Aug 7;20(15):2748-2755
DOI: 10.1039/D0LC00451K

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Velasco-Olmo, A., Ormaetxea Gisasola, J., Martinez Galvez, J. M., Vera Lillo, J., & Shnyrova, A. V.

Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers.
Scientific Reports, 2019, 9(1), 7255
DOI: 10.1038/s41598-019-43561-4

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Espadas, J., Pendin, D., Bocanegra, R., Escalada, A., Misticoni, G., Trevisan, T., Daga, A.

Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon.
Nature Communications, 2019, 10(1), 5327.
DOI: 10.1038/s41467-019-13327-7