Mechanisms of Celullar Membrane Remodelling Laboratory

Group leader
Anna Shnyrova
Phone
(+34) 94 601 8006
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

It all began some 2 billion years ago, when endosymbiosis changed forever the internal world of eukaryotic cells. The sudden engulfment of bacteria, allowed the eukaryotic cells to have an alternative source of energy, but another important evolution step took place through the symbiosis. This mostly overlooked event was the birth of a new protein family, called dynamins, that took control over the dynamics of the endomembrane systems in Eukaryotes. We want to understand how the evolution of dynamins correlates with that of endomembrane systems.

Group members
University Lecturer
Publications

Juan Manuel Martinez Galvez, Maite Garcia-Hernando, Fernando Benito-Lopez, Lourdes Basabe-Desmonts and Anna V. Shnyrova

Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes. Lab Chip,2020,20,2748
https://doi.org/10.1039/D0LC00451K

Velasco-Olmo, A., Ormaetxea Gisasola, J., Martinez Galvez, J.M. et al.

Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers. Sci Rep 9, 7255 (2019).
https://doi.org/10.1038/s41598-019-43561-4

Mukesh Mahajan, Nikhil Bharambe, Yutong Shang, Bin Lu, Abhishek Mandal, Pooja Madan Mohan, Rihua Wang, Jennifer C. Boatz, Juan Manuel Martinez Galvez, Anna V. Shnyrova, Xin Qi, Matthias Buck, Patrick C. A. van der Wel, and Rajesh Ramachandran

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission. PNAS 2021 Vol. 118 No. 29 e2023079118
https://doi.org/10.1073/pnas.2023079118

Bashkirov, P.V., Kuzmin, P.I., Chekashkina, K. et al

Reconstitution and real-time quantification of membrane remodeling by single proteins and protein complexes. Nat Protoc 15, 2443–2469 (2020).
https://doi.org/10.1038/s41596-020-0337-1

Vadim A. Frolov, Artur Escalada, Sergey A. Akimov, Anna V. Shnyrova

Geometry of membrane fission. Chemistry and Physics of Lipids 185 (2015) 129–140
https://doi.org/10.1016/j.chemphyslip.2014.07.006