Computational Systems Biophysics Laboratory

Group leader
Jose M. G. Vilar
Phone
(+34) 94 601 3450
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

Our research activity is focused on computational and mathematical analysis of biological systems at their various levels of organisation, from molecular properties to cell behaviour and the role these play in the cell population dynamics. The main objective is to deepen our understanding of the underlying mechanisms and to use this information for the controlling and designing cellular processes. For this, we use the latest computational technologies with a wide range of methods including molecular dynamics, structural bioinformatics, stochastic simulation algorithms and mathematical analysis of dynamic systems.

Group members
Ikerbasque Research Professor
Publications

1. J. A. Fernandez-Higuero, A. Muga, J. M. G. Vilar.

Extraction and Refolding Determinants of Chaperone-Driven Aggregated Protein Reactivation, J. Mol. Biol. 432, 3239-3250 (2020).

Y. Cabrera, L. Dublang, J. A. Fernandez-Higuero, D. Albesa-Jove, M. Lucas, A. R. Viguera, M. E. Guerin, J. M. G. Vilar, A. Muga, F. Moro.

Regulation of human Hsc70 ATPase and chaperone activities by Apg2: role of the acidic subdomain, J. Mol. Biol. 431, 444-461 (2019).

3. M. L. Fanani, J. V. Busto, J. Sot, J. Abad, G. Fabrias, L. Saiz, J. M. G. Vilar, F. M. Goni, B. Maggio, and A. Alonso.

Clearly Detectable, Kinetically Restricted Solid–Solid Phase Transition in cis-Ceramide Monolayers, Langmuir 34, 11749-11758 (2018).

4. J. M. G. Vilar and J. M. Rubi.

Determinants of population responses to environmental fluctuations, Scientific Reports 8: 887 (2018).