Chemical Cell Biology
Group leader
Xabier Contreras Gómez
Email
Phone
+34 946 01 2106
Address
Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)
Research goal
We aim to understand the molecular mechanisms by which lipids regulate membrane protein activities and function and the impact of such lipid/protein assemblies in a subset of human diseases (cancer, neurodegenerative) and to map membrane protein-lipid interactome networks in the cell. The long-term objective is to obtain the cell blueprint that will help to understand and overcome biological processes and their consequences in human diseases. In short, knowing how to read the cell blueprint will tell us, for instance, how and what drives cancer and what part of the networks should be target before and after the network adapts and mutates.
Group members
June Olazar Intxausti
PhD Student
Xabier Contreras Gómez
Ikerbasque Research Associate Professor
Publications
Pérez-Cruz C, Moraleda-Montoya A, Liébana R, Terrones O, Arrizabalaga U, García-Alija M, Lorizate M, Martínez Gascueña A, García-Álvarez I, Nieto-Garai JA, Olazar-Intxausti J, Rodríguez-Colinas B, Mann E, Chiara JL, Contreras FX, Guerin ME, Trastoy B, Alonso-Sáez L
Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota
Nat Commun. 2024 Dec 30;15(1):10906
doi: 10.1038/s41467-024-55268-w
Terrones O, Olazar-Intxausti J, Anso I, Lorizate M, Nieto-Garai JA, Contreras FX
Raman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseases
Int J Mol Sci. 2023 Jan 25;24(3):2384
doi: 10.3390/ijms24032384
Nieto-Garai JA, Olazar-Intxausti J, Anso I, Lorizate M, Terrones O, Contreras FX
Super-Resolution Microscopy to Study Interorganelle Contact Sites
Int J Mol Sci. 2022 Dec 5;23(23):15354
doi: 10.3390/ijms232315354
Morana O, Nieto-Garai JA, Björkholm P, Bernardino de la Serna J, Terrones O, Arboleya A, Ciceri D, Rojo-Bartolomé I, Blouin CM, Lamaze C, Lorizate M, Contreras FX.
Identification of a New Cholesterol-Binding Site within the IFN-γ Receptor that is Required for Signal Transduction
Adv Sci (Weinh). 2022 Apr;9(11):e2105170. PMID: 35166455
DOI: 10.1002/advs.202105170
Nieto-Garai JA, Olazar-Intxausti J, Anso I, Lorizate M, Terrones O, Contreras FX
Super-Resolution Microscopy to Study Interorganelle Contact Sites
Int J Mol Sci. 2022:15354. PMID: 36499680.
DOI: 10.3390/ijms232315354
Nieto-Garai JA, Contreras FX, Arboleya A, Lorizate M
Role of Protein-Lipid Interactions in Viral Entry
Adv Biol (Weinh). 2022 Mar;6(3):e2101264. PMID: 35119227
DOI: 10.1002/adbi.202101264
Nieto-Garai JA, Lorizate M, Contreras FX
Shedding light on membrane rafts structure and dynamics in living cells
Biochim Biophys Acta Biomembr. 2022 Feb 1;1864(1):183813. PMID: 34748743
DOI: 10.1016/j.bbamem.2021.183813
Anso I, Basso LGM, Wang L, Marina A, Páez-Pérez ED, Jäger C, Gavotto F, Tersa M, Perrone S, Contreras FX, Prandi J, Gilleron M, Linster CL, Corzana F, Lowary TL, Trastoy B, Guerin ME
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA
Sci Adv. 2021 Oct 15;7(42):eabj4565. PMID: 34652941
DOI: 10.1126/sciadv.abj4565
Lorizate M, Terrones O, Nieto-Garai JA, Rojo-Bartolomé I, Ciceri D, Morana O, Olazar-Intxausti J, Arboleya A, Martin A, Szynkiewicz M, Calleja-Felipe M, Bernardino de la Serna J, Contreras FX
Super-Resolution Microscopy Using a Bioorthogonal-Based Cholesterol Probe Provides Unprecedented Capabilities for Imaging Nanoscale Lipid Heterogeneity in Living Cells
Small Methods. 2021 Sep;5(9):e2100430. PMID: 34928061.
DOI: 10.1002/smtd.202100430
Nieto-Garai JA, Arboleya A, Otaegi S, Chojnacki J, Casas J, Fabriàs G, Contreras FX, Kräusslich HG, Lorizate M
Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering
Adv Sci (Weinh). 2020 Dec 21;8(3):2003468. PMID: 33552873.
DOI: 10.1002/advs.202003468