Cell Membrane Organisation and Dynamics Laboratory

Group leader
Adai Colom Diego
Phone
946018051
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

We aim to understand the role of membrane mechanics and protein dynamics involved in different cellular processes. In particular, we are focussed on immunological synapse, viral infection and embriogenesis. We use a wide range of systems (u to embryos) and technics, particularly HS-AFM and Fast-FLIM.

Group members
Postdoctoral Fellow
Ramon y Cajal Fellow / Ikerbasque Reseach Fellow
Publications

Franco A, Gracia P, Colom A, Camino JD, Fernández-Higuero JÁ, Orozco N, Dulebo A, Saiz L, Cremades N, Vilar JMG, Prado A, Muga A.

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105548118. PMID: 34462355
10.1073/pnas.2105548118.

Mahecic D, Carlini L, Kleele T, Colom A, Goujon A, Matile S, Roux A, Manley S.

Mitochondrial membrane tension governs fission
Cell Rep. 2021 Apr 13;35(2):108947. PMID: 33852852
10.1016/j.celrep.2021.108947

Zuttion F, Colom A, Matile S, Farago D, Pompeo F, Kokavecz J, Galinier A, Sturgis J, Casuso I.

High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action.
Nat Commun. 2020 Dec 9;11(1):6312. PMID: 33298927
10.1038/s41467-020-19710-z

Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H. Curr Biol.

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
2020 Aug 20:S0960-9822(20)31084-8.  
10.1016/j.cub.2020.07.059

García-Calvo J, Maillard J, Fureraj I, Strakova K, Colom A, Mercier V, Roux A, Vauthey E, Sakai N, Fürstenberg A, Matile S. J Am Chem Soc.  Epub 2020 Jul 1

Fluorescent Membrane Tension Probes for Super-Resolution Microscopy: Combining Mechanosensitive Cascade Switching with Dynamic-Covalent Ketone Chemistry.
2020 Jul 15;142(28):12034-12038.
10.1021/jacs.0c04942.

T. Sansen, D. Sanchez-Fuentes, R. Rathar, A. Colom-Diego, F. El Alaoui, J. Viaud, M. Macchione, S. de Rossi, S. Matile, R. Gaudin, V. Bäcker, A. Carretero-Genevrier*, and L. Picas. ACS Appl. Mater. Publication Date:May 28, 2020.

Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography.
Interfaces 2020, 12, 26, 29000–29012
10.1021/acsami.0c05432

Goujon A, Colom A, Straková K, Mercier V, Mahecic D, Manley S, Sakai N, Roux A, Matile S. J Am Chem Soc. Epub 2019 Feb 12

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes.
2019 Feb 27;141(8):3380-3384. 
10.1021/jacs.8b13189.

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R. Nat Cell Biol. Epub 2018 Aug 27.

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
2018 Sep;20(9):1043-1051. 
10.1038/s41556-018-0150-z.

Colom A, Derivery E, Soleimanpour S, Tomba C, Molin MD, Sakai N, González-Gaitán M, Matile S, Roux A. Nat Chem. Epub 2018 Aug 27.

A fluorescent membrane tension probe.
2018 Nov;10(11):1118-1125. 
10.1038/s41557-018-0127-3.