Cell Membrane Organisation and Dynamics Laboratory

Group leader
Adai Colom Diego

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

We aim to understand the role of membrane mechanics and protein dynamics involved in different cellular processes. In particular, we are focussed on immunological synapse, viral infection and embriogenesis. We use a wide range of systems (u to embryos) and technics, particularly HS-AFM and Fast-FLIM.

Group members
Postdoctoral Fellow
Ramon y Cajal Fellow / Ikerbasque Reseach Fellow

Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H. Curr Biol.

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
2020 Aug 20:S0960-9822(20)31084-8.  

García-Calvo J, Maillard J, Fureraj I, Strakova K, Colom A, Mercier V, Roux A, Vauthey E, Sakai N, Fürstenberg A, Matile S. J Am Chem Soc.  Epub 2020 Jul 1

Fluorescent Membrane Tension Probes for Super-Resolution Microscopy: Combining Mechanosensitive Cascade Switching with Dynamic-Covalent Ketone Chemistry.
2020 Jul 15;142(28):12034-12038.

T. Sansen, D. Sanchez-Fuentes, R. Rathar, A. Colom-Diego, F. El Alaoui, J. Viaud, M. Macchione, S. de Rossi, S. Matile, R. Gaudin, V. Bäcker, A. Carretero-Genevrier*, and L. Picas. ACS Appl. Mater. Publication Date:May 28, 2020.

Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography.
Interfaces 2020, 12, 26, 29000–29012

Oberhauser L, Granziera S, Colom A, Goujon A, Lavallard V, Matile S, Roux A, Brun T, Maechler P.Biochim Biophys Acta Mol Cell Res. Epub 2019 Dec 7

Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling.
2020 Feb;1867(2):118619. 

Kadosh A, Colom A, Yellin B, Roux A, Shemesh T. Proc Natl Acad Sci U S A. Epub 2019 Jun 12.

The tilted helix model of dynamin oligomers.
2019 Jun 25;116(26):12845-12850. 

Goujon A, Colom A, Straková K, Mercier V, Mahecic D, Manley S, Sakai N, Roux A, Matile S. J Am Chem Soc. Epub 2019 Feb 12

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes.
2019 Feb 27;141(8):3380-3384. 

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R. Nat Cell Biol. Epub 2018 Aug 27.

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
2018 Sep;20(9):1043-1051. 

Colom A, Derivery E, Soleimanpour S, Tomba C, Molin MD, Sakai N, González-Gaitán M, Matile S, Roux A. Nat Chem. Epub 2018 Aug 27.

A fluorescent membrane tension probe.
2018 Nov;10(11):1118-1125. 

Tanasescu R, Mettal U, Colom A, Roux A, Zumbuehl A. Polymers (Basel).

Facile and Rapid Formation of Giant Vesicles from Glass Beads.
2018 Jan 9;10(1):54.