Cell Membrane Organisation and Dynamics
Group leader
Adai Colom Diego
Email
Phone
+34 946 01 8051
Address
Biofisika Institute (CSIC, EHU)
Science Park of the EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)
Research goal
We aim to understand the role of membrane mechanics and protein dynamics involved in different cellular processes. In particular, we are focussed on immunological synapse, viral infection and embriogenesis. We use a wide range of systems (u to embryos) and technics, particularly HS-AFM and Fast-FLIM.
Group members
Aimar Marauri
PhD Student
Claire Elisabeth Buchanan
Postdoctoral Fellow
Laura Iglesias
PhD Student
Carlos Marcuello
Postdoctoral Fellow
Marián Alonso
Research Technician
Adai Colom Diego
Ramon y Cajal Fellow | Ikerbasque Reseach Fellow
Andrea Merino Arrese
Phd Student
Publications
Campos Pacheco JE, Vitali A, Falkman P, Marauri A, Marchès A, Al-Najjar H, Colom A, Cárdenas M, Pilkington GA, Valetti S.
Bioinspired lipid coated porous particle as inhalable carrier with pulmonary surfactant adhesion and mucus penetration
J Colloid Interface Sci. 2025 Nov;697:137967. PMID: 40449392.
10.1016/j.jcis.2025.137967
del Rocio Lopez-Buenafe G, Alonso-Cabrera JA, Marcuello C, Ortiz-Perez M, Benito-Lopez F, Colom A, Basabe-Desmonts L, Saez J
Fabrication and Characterization of PEDOT:PSS-based Microstructured Electrodes for in vitro Cell Culture
Advanced Materials Interfaces 2025 12;20.
10.1002/admi.202500097
García-Arcos JM, Mehidi A, Sanchez-Velasquez J, Guillamat P, Tomba C, Houzet L, Capolupo L, Espadas J, D'Angelo G, Colom A, Hinde E, Aumeier C, Roux A
Adherent Cells Sustain Membrane Tension Gradients Independently of Migration
Nat Commun. 2025 Nov 26;16(1):10539. PMID: 41298393; PMCID: PMC12657936.
10.1038/s41467-025-65571-9.
Naskar S, Merino A, Espadas J, Singh J, Roux A, Colom A, Low HH
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
Nat Struct Mol Biol. 2025 Mar;32(3):571-584
doi: 10.1038/s41594-024-01401-8
Auria-Luna F, Foss FW Jr, Molina-Canteras J, Velazco-Cabral I, Marauri A, Larumbe A, Aparicio B, Vázquez JL, Alberro N, Arrastia I, Nacianceno VS, Colom A, Marcuello C, Jones BJP, Nygren D, Gómez-Cadenas JJ, Rogero C, Rivilla I, Cossío FP, The Next Collaboration
Supramolecular chemistry in solution and solid-gas interfaces: synthesis and photophysical properties of monocolor and bicolor fluorescent sensors for barium tagging in neutrinoless double beta decay
RSC Appl Interfaces. 2024 Nov 4;2(1):185-199
doi: 10.1039/d4lf00227j
Rodriguez-Lejarraga P, Martin-Iglesias S, Moneo-Corcuera A, Colom A, Redondo-Morata L, Giannotti MI, Petrenko V, Monleón-Guinot I, Mata M, Silvan U, Lanceros-Mendez S.
The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
Acta Biomater. 2024 Jun 29:S1742-7061(24)00352-0.
doi: 10.1016/j.actbio.2024.06.039
Huang Y, Chandran Suja V, Yang M, Malkovskiy AV, Tandon A, Colom A, Qin J, Fuller GG
Interfacial stresses on droplet interface bilayers using two photon fluorescence lifetime imaging microscopy
J Colloid Interface Sci. 2024 Jan;653(Pt B):1196-1204
doi: 10.1016/j.jcis.2023.09.092
Franco A, Gracia P, Colom A, Camino JD, Fernández-Higuero JÁ, Orozco N, Dulebo A, Saiz L, Cremades N, Vilar JMG, Prado A, Muga A.
All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105548118
DOI: 10.1073/pnas.2105548118
Mahecic D, Carlini L, Kleele T, Colom A, Goujon A, Matile S, Roux A, Manley S.
Mitochondrial membrane tension governs fission
Cell Rep. 2021 Apr 13;35(2):108947
DOI: 10.1016/j.celrep.2021.108947
Zuttion F, Colom A, Matile S, Farago D, Pompeo F, Kokavecz J, Galinier A, Sturgis J, Casuso I.
High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action.
Nat Commun. 2020 Dec 9;11(1):6312
DOI: 10.1038/s41467-020-19710-z
Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H.
Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
Curr Biol. 2020 Aug 20:S0960-9822(20)31084-8.
DOI: 10.1016/j.cub.2020.07.059
García-Calvo J, Maillard J, Fureraj I, Strakova K, Colom A, Mercier V, Roux A, Vauthey E, Sakai N, Fürstenberg A, Matile S.
Fluorescent Membrane Tension Probes for Super-Resolution Microscopy: Combining Mechanosensitive Cascade Switching with Dynamic-Covalent Ketone Chemistry.
J Am Chem Soc. 2020 Jul 15;142(28):12034-12038
DOI: 10.1021/jacs.0c04942
T. Sansen, D. Sanchez-Fuentes, R. Rathar, A. Colom-Diego, F. El Alaoui, J. Viaud, M. Macchione, S. de Rossi, S. Matile, R. Gaudin, V. Bäcker, A. Carretero-Genevrier*, and L. Picas.
Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography.
ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29000-29012
DOI: 10.1021/acsami.0c05432
Goujon A, Colom A, Straková K, Mercier V, Mahecic D, Manley S, Sakai N, Roux A, Matile S.
Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes.
J Am Chem Soc. 2019 Feb 27;141(8):3380-3384
DOI: 10.1021/jacs.8b13189
Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.
Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Nat Cell Biol. 2018 Sep;20(9):1043-1051
DOI: 10.1038/s41556-018-0150-z
Colom A, Derivery E, Soleimanpour S, Tomba C, Molin MD, Sakai N, González-Gaitán M, Matile S, Roux A.
A fluorescent membrane tension probe.
Nat Chem. 2018 Nov;10(11):1118-1125
DOI: 10.1038/s41557-018-0127-3