Cell Membrane Organisation and Dynamics

Group leader
Adai Colom Diego
+34 946 01 8051

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

We aim to understand the role of membrane mechanics and protein dynamics involved in different cellular processes. In particular, we are focussed on immunological synapse, viral infection and embriogenesis. We use a wide range of systems (u to embryos) and technics, particularly HS-AFM and Fast-FLIM.

Group members
Marie Curie Postdoctoral Fellow
Postdoctoral Fellow
Postdoctoral Fellow
PhD Student
Research Technician
Ramon y Cajal Fellow / Ikerbasque Reseach Fellow

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Huang Y, Chandran Suja V, Yang M, Malkovskiy AV, Tandon A, Colom A, Qin J, Fuller GG
Interfacial stresses on droplet interface bilayers using two photon fluorescence lifetime imaging microscopy
J Colloid Interface Sci. 2024 Jan;653(Pt B):1196-1204
doi: 10.1016/j.jcis.2023.09.092

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Franco A, Gracia P, Colom A, Camino JD, Fernández-Higuero JÁ, Orozco N, Dulebo A, Saiz L, Cremades N, Vilar JMG, Prado A, Muga A.

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105548118
DOI: 10.1073/pnas.2105548118

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Mahecic D, Carlini L, Kleele T, Colom A, Goujon A, Matile S, Roux A, Manley S.

Mitochondrial membrane tension governs fission
Cell Rep. 2021 Apr 13;35(2):108947
DOI: 10.1016/j.celrep.2021.108947

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Zuttion F, Colom A, Matile S, Farago D, Pompeo F, Kokavecz J, Galinier A, Sturgis J, Casuso I.

High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action.
Nat Commun. 2020 Dec 9;11(1):6312
DOI: 10.1038/s41467-020-19710-z

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Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H.

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
Curr Biol. 2020 Aug 20:S0960-9822(20)31084-8.  
DOI: 10.1016/j.cub.2020.07.059

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García-Calvo J, Maillard J, Fureraj I, Strakova K, Colom A, Mercier V, Roux A, Vauthey E, Sakai N, Fürstenberg A, Matile S.

Fluorescent Membrane Tension Probes for Super-Resolution Microscopy: Combining Mechanosensitive Cascade Switching with Dynamic-Covalent Ketone Chemistry.
J Am Chem Soc. 2020 Jul 15;142(28):12034-12038
DOI: 10.1021/jacs.0c04942

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T. Sansen, D. Sanchez-Fuentes, R. Rathar, A. Colom-Diego, F. El Alaoui, J. Viaud, M. Macchione, S. de Rossi, S. Matile, R. Gaudin, V. Bäcker, A. Carretero-Genevrier*, and L. Picas.

Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography.
ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29000-29012
DOI: 10.1021/acsami.0c05432

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Goujon A, Colom A, Straková K, Mercier V, Mahecic D, Manley S, Sakai N, Roux A, Matile S.

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes.
J Am Chem Soc. 2019 Feb 27;141(8):3380-3384
DOI: 10.1021/jacs.8b13189

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Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Nat Cell Biol. 2018 Sep;20(9):1043-1051
DOI: 10.1038/s41556-018-0150-z

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Colom A, Derivery E, Soleimanpour S, Tomba C, Molin MD, Sakai N, González-Gaitán M, Matile S, Roux A.

A fluorescent membrane tension probe.
Nat Chem. 2018 Nov;10(11):1118-1125
DOI: 10.1038/s41557-018-0127-3