Biophysics of Morphogenesis Laboratory

Group leader
Jérôme Solon
Phone
+34 946 015 134
Address

Biofisika Institute (CSIC-UPV/EHU)
Basque Excellence Research Center
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Research goal

Our group is interested in understanding the mechanisms at the origin of force generation, coordination and regulation in biological tissues during animal development. Our group uses an interdisciplinary approach, combining expertise in Drosophila genetics and molecular biology with high-resolution live imaging, biophysical analysis and modelling, with the aim of building a quantitative description of the mechano-chemical properties of the morphogenetic processes occurring during Drosophila Melanogaster embryogenesis.

Group members
PhD Student
Postdoctoral Fellow
Distinguished University Researcher / Ikerbasque Research Professor
PhD Student
Publications

D’Angelo A, Dierkes K., Carolis C., Salbreux G., Solon J.

In vivo force application reveals a fast tissue softening and external friction increase during early embryogenesis. Curr Biol. 2019 May 6;29(9):1564-1571.
PubMed PMID: 31031116.

D’Angelo A., Godeau A.L., Solon J.

A new player in tissue mechanics: MicroRNA control of mechanical homeostasis. Dev Cell. 2019 Mar 11;48(5):596-598.
PubMed PMID: 30861373.

Sumi A., Hayes P., D’Angelo A., Colombelli J., Salbreux G., Dierkes K., Solon J.

Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling. Dev Cell. 2018 Nov 19;47(4):453-463.
PubMed PMID: 30458138.

Agmon E., Solon J., Bassereau P., Stockwell B.R.

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties Sci Rep. 2018 Mar 26;8(1):5155.
PubMed PMID: 29581451.

Fraire-Zamora J.J., Jaeger J., Solon J.

Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita. Elife. 2018 Mar 14;7. Pii:e33807.
PubMed PMID: 29537962.